1
The Coil Creates a Magnetic Field
A TMS coil rests against your scalp. When the machine turns on, the coil creates a brief magnetic field.
TMS made simple
How TMS Works
TMS uses a rapidly changing magnetic field to affect electrical activity in a small area of the brain. No electricity is sent through your scalp, and nothing is placed inside your brain.
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2
The Magnetic Field Reaches the Brain
The field passes safely through the scalp and skull. It creates a very small electrical current in the brain tissue below the coil.
3
Nearby Brain Cells Become Active
That current changes the activity of nearby nerve cells. iTBS delivers the magnetic pulses in a specific, repeating pattern.
4
Repeated Sessions May Change the Response
One session creates a short period of stimulation. Repeated sessions may change how strongly brain cells communicate.
What is neuroplasticity?
How Brain Cells Learn From Repetition
Neuroplasticity is the brain’s ability to change how its cells communicate. Learning a skill, forming a memory, and adapting to repeated experiences all depend on plasticity.
TMS is thought to use some of these same learning-like processes. Repeated stimulation can change the strength of signaling between nerve cells.
BEFORE STIMULATION
Normal subtle signaling
REPEATED TMS
Planned pulses and pauses
OVER TIME
Cells may respond differently
This is a teaching graphic, not a brain scan or a promise of permanent change.
Why one-day TMS?
What Makes the ONE-D Approach Different?
Standard TMS
Usually one treatment session each weekday, repeated over several weeks.
20
Short iTBS Sessions Across One Day
Twenty brief, patterned sessions with planned time between them.
A Shorter Session Format
iTBS means intermittent theta burst stimulation. It delivers magnetic pulses in repeating bursts, allowing each treatment session to be much shorter than many standard TMS sessions.
Repeated, Spaced Sessions
The 2025 ONE-D study began sessions about every 30 minutes. This allowed 20 sessions across about 9.5 hours. The breaks are part of the planned protocol; stimulation is not continuous.
Neuroplasticity Augmentation
Valiant plans to use D-cycloserine before treatment when clinically appropriate. It acts on NMDA receptors involved in learning and neuroplasticity and has been studied as a way to enhance the brain’s response to repeated TMS.
Off-label use: the FDA has not specifically approved D-cycloserine for TMS augmentation. It does not guarantee a stronger response.
ONE-D differs from standard TMS in more than scheduling. It combines short iTBS sessions, closely planned repetition, and an off-label neuroplasticity augmenter in one accelerated protocol.
What the research found
What Did the ONE-D Study Find?
The published ONE-D case series followed 32 adults with depression after a single-day treatment regimen.
At 6 weeks · HDRS-17
What Happened to the 32 People in the Study?
23
REACHED REMISSION
Symptoms fell into the study’s very-low range.
5
RESPONDED, NOT IN REMISSION
Symptoms improved by at least half but stayed above the remission cutoff.
4
DID NOT MEET RESPONSE CUTOFF
Scores did not improve by at least half at six weeks.
28 of 32
RESPONDED
The 23 people in remission plus 5 more responders equals 28 people whose scores improved by at least half.
23 of 32
REACHED REMISSION
About 72% had scores fall into the study’s remission range.
Improvement Built Over Time
The study showed a delayed pattern. Most improvement happened during the weeks after treatment, not during the treatment day itself.
TREATMENT DAY
Little immediate change for many patients
WEEK 1
Some improvement
WEEKS 2–3
More patients met response or remission criteria
WEEKS 4–6
Improvement leveled off for many patients
What about 6 months later?
16/32
STILL IN REMISSION
Half of the original group.
2/32
STILL RESPONDED
At least 50% better, but above the remission cutoff.
8/32
RELAPSED OR RETREATED
One in four relapsed or had more treatment.
6/32
LOST TO FOLLOW-UP
No 6-month outcome data were available.
These numbers use all 32 original participants, not only the people who returned for follow-up.
What This Study Cannot Tell Us
32 PEOPLE
It was a small study.
NO PLACEBO
There was no comparison group.
OPEN-LABEL
Patients and clinicians knew treatment was being given.
DIFFERENT PROTOCOL
Valiant’s medication plan is not identical to the published regimen.
Larger randomized studies are needed.
Source: Vaughn et al. Published ONE-D case series.
Before and after treatment
We Screen Before We Treat
- Tell us about any seizure history.
- Tell us about implants or metal near your head.
- Tell us about major concussions, skull injury, or brain surgery.
- We review everything you take.
- Tell us about hearing problems, tinnitus, or frequent migraines.
A “yes” does not always mean you cannot have TMS. It means we need to review it.
We Follow the Change Over Time
TREATMENT COMPLETE
One planned treatment day.
2-WEEK CHECK
Mood, anxiety, and daily life.
6-WEEK REVIEW
Response and next-step plan.
CONTINUED CARE
Reassessment when needed.
If improvement is incomplete, symptoms return, or medication questions come up, we reassess what is happening and talk through the next step.
Side effects + risks
What Should I Know?
Most side effects are felt during or shortly after treatment. Serious risks are uncommon, but they matter and are reviewed before you begin.
Scalp discomfort
Headache
Jaw discomfort
Muscle twitching
Lightheadedness
Rare seizure risk
Rare mood elevation or mania
Your evaluation and informed-consent process cover your personal risks in more detail.
Cost + next step
ONE-D May Be Worth Exploring If...
Symptoms are still affecting life.
Medication, therapy, or both have not helped enough.
Weeks of repeat visits are hard to fit into your life.
ONE-D TREATMENT
$2,995
Cash-pay treatment fee
Psychiatric evaluation and follow-up visits are separate psychiatric services. When Valiant is in-network and the visit is eligible under your plan, we can bill those visits to insurance.
SELF-PAY EVALUATION
$300
If you pay $300 for your evaluation and later proceed with ONE-D, that $300 is applied toward the $2,995 ONE-D price. The remaining ONE-D balance is $2,695. This credit does not apply to an insurance-billed evaluation.
September availability
5 September treatment spots available
Each ONE-D patient receives a full treatment day, dedicated clinical care, and a private treatment suite. A consultation or evaluation does not reserve a treatment spot.
You Do Not Need to Know If TMS Is Right for You.
That is what the first conversation is for.
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Medical Information
This page is educational. It is not a diagnosis or treatment recommendation. TMS and D-cycloserine are not right for everyone. D-cycloserine use with TMS is off-label. A full psychiatric and safety evaluation comes before treatment.